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NNVClover

10/03/10 7:43 PM

#38831 RE: Nanotoday #38830

Let's see some viral log curves. HAART has no delivery issue with respect to ADME. For humans, we've reached the final frontier for HIV therapy - clearing the virus from the blood is easily achievable with one pill (Atripla) - we need something that will clear it from the reservoirs where the antivirals can't reach.

From Seymour's comments ("we don't work inside cells") and his comment at 8:00 where he notes "that's a whole other project" with respect to tackling herpes virus which is hidden latent in nerve cells, I suspect NNVC does not have the technology to tackle HIV. The facts are simple.

Rabies? That seems interesting.
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NNVClover

10/03/10 7:49 PM

#38833 RE: Nanotoday #38830

Don't forget there are almost no good preclinical assays for HIV. You really need to prove human efficacy. So without a lead candidate nomination with GMP/GLP pharmatox, etc followed by an IND submission - we're just guessing on the HIV results and their ability to translate to humans.
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Ubertino

10/03/10 8:13 PM

#38837 RE: Nanotoday #38830

Sounds like it! But perhaps with the same dosage as the HAART cocktail the NNVC results are 25 times better. Hard to say from that blurb you referred to.