Replies to post #2047 on Ariad Pharmaceuticals Inc fka ARIA

[IIIverson]

sounds great. thank you!

[bellweather1]

My position, though a slightly uncomfortable one at times like this, is set as well.

I agree on the ponatinib trial design-sure would allow for an early T315I approval, which I believe is reasonably likely, without disrupting the rest of the trial, the results of which could ultimately have positive implications for 534's viability in 1st and 2nd line indications.

Do you agree with a few of us that a positive rida/endo result could really light a fire here? What's your latest thinkng on the odds of this?

This has really been a difficult and disappointing last couple of weeks in biotech and ariad-though I knew this end of the quarter/news vacuum scenario was a real possibility, I had hoped for more.

In any event, please advise concerning the above,thanks for your response, and please check in from time to time on the "substantive" topics du jour.

Best,

bw

[wrkingcapital]

Don
I know that you've evaluated the Rida phase 3 design before and I believe the focus has been learnings from phase 2 were utilized to increase the likleyhood of success in Phase 3.... specifically there was an indication that a population of patients in phase 2 had a greater response than others i.e.."Results of a recent study of specimens from patients with high-grade sarcomas suggested that the level of expression of phosphorylated S6 was predictive of tumor response to ridaforolimus"...and also that the end points were altered and progression free subjects were the focus to allow Rida effects more time to develop...I guess I am asking if your analysis has any new components to it and could you note in response your overall view of the prospects for success....As always the board appreciates your input..

[Paulieme]

Thursday, September 23, 2010:(Bledsoe Battle) << "We hope that TODAY is the day for Tyler to begin on Ponatinib (the new name for the Ariad drug)!">> Our hope here on this MB is of monetary values. We have to say prayers for the Bledsoe family,and others going into these trials!(I just lost my sister 6/9/10,to cancer).Paulie. http://bledsoebattle.blogspot.com/

[joyakid]

Hello Don,

I am 100 % with you and concur. I, too, am long ARIA and - researching/believing in its science; trials, doing DD, have supported ARIAD for a few years. Interesting to read about case studies and existing trials.

Thanks for contributing here.

Best,

j..