You misunderstand!!! No responsible oncologist would say anything of the sort. What I meant (obviously) is that in designing the trials, Ariad and Sarcoma specialists ("thought leaders" in Dr.Berger's words) had a vast array of data, years of clinical feedback to utilize, in order to select a patient population and a trial protocol that was likely to result in a successful outcome. SUCCEED is not a shot in the dark! The unnamed "analysts" you cite, are clearly disadvantaged by lack of relevant data, and a substantial lack of seriousness in their prognostications.