The phase-3 VELOUR study tested FOLFIRI ± aflibercept in patients who had progressed on FOLFOX in the first-line setting. Details will be presented at an unspecified medical meeting. (It may be too late for ASCO.)
The new brand name for aflibercept in cancer is Zaltrap.
Patients with metastatic colorectal cancer (mCRC) previously treated with oxaliplatin were randomized to receive ZALTRAP or placebo in combination with the FOLFIRI regimen (irinotecan-5-fluorouracil-leucovorin). The addition of ZALTRAP to the FOLFIRI regimen significantly improved both overall survival (HR=0.817; p=0.0032) and progression-free survival (HR=0.758; p=0.00007). A similar effect was seen with ZALTRAP therapy whether or not patients had received prior bevacizumab therapy.
The phase-3 VELOUR study tested FOLFIRI ± Zaltrap in patients who had progressed on FOLFOX in the first-line setting. SNY/REGN reported in April that this study hit its OS primary endpoint (#msg-62465993), but the hazard ratios and p-values were unknown until today. Description of the VELOUR study is at http://clinicaltrials.gov/ct2/show/NCT00561470 . Full data will be reported at ESMO on 6/25/11.