MRSA can be fatal. In 1974, MRSA infections accounted for two percent of the total number of staph infections; in 1995 it was 22%; in 2004 it was 63%. CDC estimated that 94,360 invasive MRSA infections occurred in the United States in 2005; 18,650 of these were associated with death. MRSA is resistant to antibiotics including methicillin, oxacillin, penicillin, and amoxicillin. Since these strong drugs are not effective with MRSA, these infections are sometimes called Multidrug-Resistant Organisms (MDROs). Staph infections, including MRSA, occur most often among people in hospitals and healthcare facilities (such as nursing homes and dialysis centers) who have weakened immune systems. The infection can be spread by skin-to-skin contact, sharing or touching a personal item with someone with infected skin, or touching a surface or item that has been in contact with someone with MRSA.