I have held company stocks that were taken over going back as far 1986, and there have been times where I lost my ass holding the stock while it dropped, and then got taken over at a rock bottom fire sale price (they took it private)leaving me no chance to ride a rebound back up to recover my losses. I have also been lucky with one last year that I bought near the bottom, it was so oversold it was bought out at a 600% premium over its recent low, that I made a 500% profit on the move to take it private in about 30 days after buying near the bottom. I doubt ANX would be bought and taken private, but if the buy out price is poor, and it was bought by a big outfit with a stable stock price, don't count on a move up after the buy out.