co3aii, would you not expect that genotypes contrasting between the Republic of Georgia and India would be pretty diverse? The US has been a melting pot of immigration, so it would be a challenge to reconcile all genotypes through trial design. However, showing efficacy in two areas as diverse as Georgia and India would suggest Bavi isn't likely genotype limited. Of course, if there is a big difference in efficacy for the same cancer between the two trials, that would raise a flag, but if both trials are showing good results.......
Best wishes and IMO.
KT