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iggs

12/23/08 9:20 AM

#22417 RE: gfp927z #22416

Form 8-K for CORTEX PHARMACEUTICALS INC/DE/


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23-Dec-2008

Entry into a Material Definitive Agreement, Change in Directors or



Item 1.01 Entry into a Material Definitive Agreement.
On December 22, 2008, Cortex Pharmaceuticals, Inc. (the "Company") entered into an Amendment No. 2 to Employment Agreement (the "Coleman Amendment") with James H. Coleman, the Company's Senior Vice President, Business Development, which amends his Employment Agreement with the Company dated as of May 17, 2000, as amended January 1, 2004 (the "Employment Agreement"), and an Amendment No. 1 to Severance Agreement (the "Messinger Amendment") with Maria S. Messinger, the Company's Vice President and Chief Financial Officer, which amends her Severance Agreement with the Company dated as of October 26, 2000 (the "Severance Agreement"). The Coleman Amendment and the Messinger Amendment are referred to herein collectively as the "Amendments" and the Employment Agreement and the Severance Agreement are referred to herein collectively as the "Agreements."

The Company entered into the Amendments for the purpose of bringing the Agreements into compliance with the applicable provisions of Section 409A of the Internal Revenue Code of 1986, as amended, and the Treasury Regulations issued thereunder. Section 409A governs "nonqualified deferred compensation" arrangements. Section 409A imposes penalties and additional tax on service providers (including employees and directors) if a nonqualified deferred compensation arrangement does not comply with its provisions. The Coleman Amendment modifies the definition of termination for "good reason" and related procedures to comply with Section 409A, clarifies that any severance payments which are treated as non-qualified deferred compensation must be made upon a "separation of service" with the Company and that, subject to certain exceptions, such payments may be delayed for a period of six months if Mr. Coleman is deemed to be a "specified employee" at the time of his termination of employment and provides that certain other payments, including expense reimbursements, will be made only at times permissible without triggering tax penalties under Section 409A. The Messinger Amendment modifies the definition of termination for "good reason" and related procedures to comply with Section 409A and clarifies that any severance payments which are treated as non-qualified deferred compensation must be made upon a "separation of service" with the Company and that, subject to certain exceptions, such payments may be delayed for a period of six months if Ms. Messinger is deemed to be a "specified employee" at the time of her termination of employment.

The foregoing descriptions of the Coleman Amendment and the Messinger Amendment do not purport to be complete and are qualified in their entirety by reference to the full texts of the Coleman Amendment and the Messinger Amendment, copies of which are attached hereto as Exhibit 10.110 and Exhibit 10.111, respectively, and are incorporated herein by reference.





Item 5.02 Departure of Directors or Certain Officers; Election of Directors;
Appointment of Principal Officers; Compensatory Arrangements of Certain Officers.
See the disclosures set forth under Item 1.01 regarding the Coleman Amendment and the Messinger Amendment, which are incorporated by reference into this Item 5.02.



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neuroinv

12/23/08 9:58 AM

#22421 RE: gfp927z #22416

I'm not a big fan. 03140 is the drug which first had spectacular Phase IIa results reported, too good to be true. And a couple weeks later, Epix reported that they weren't, there was a math error--though they still did hit .05. It's in Phase IIb, but it's one of many symptomatic candidates out there. 00023 failed in depression, 07034 was found to have QTc problems. Epix had backburnered everything but the AD and COPD programs. Even their previous partner had renounced the Vasovist partnership.

Now the FDA approval lights a fire under the share value. I wish I'd owned a ton yesterday morning. It's a nice holiday gift for Elkan Gamzu, the acting-CEO. But I personally have no inclination to chase Epix.

NeuroInvestment