Scstocks, Thanks for the slides. In the most detailed slide (showing CX-701 restoring Fentanyl induced RD), it appears to take 90 minutes to fully restore respiration to pre-Fentanyl levels. Assuming I'm interpreting the graphs correctly, in this in-vivo rat model, Fentanyl takes about 2 minutes to start affecting respiration rate, greatly reducing the rate of breathing, though the depth/amplitude of breathing appears to still be fairly normal. By minute 4 the breathing rate appears extremely erratic. Then CX-701 is given, and by minute 9 respiration appears to return to roughly how it was 2 minutes after the Fentanyl (reduced breathing rate but depth/amplitude fairly normal). Then something odd appears to happen - the rate of breathing gets back to normal (minute 13), but the depth/amplitude of breathing gets considerably more shallow. Then, between minute 20 and 60 the depth/amplitude of breathing gradually increases, and is fully restored by minute 90.
I'd like to see a comparable graph of how Narcan works in this model since that is the current standard of care for RD reversal. If Narcan works faster/better than the Ampakine, then the only advantage an Ampakine would have in the rescue setting would be that it doesn't eliminate the pain reducing efficacy of the opiate med. That may be an important distinction, but it would be secondary to the primary goal of saving the patient's life by restoring respiration as quickly as possible.
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