Re Genvec: 1) The FDA probably asked for the change to overall survival. It's the gold standard and easily understood and appreciated by every oncologist. I assume the company went along with the request because, in return, they have a good chance at earlier than expected positive results with application approval based thereon + interim peeks with minimal statistical burden. That reduces their cost. A change from 1 year survival to overall survival will surely include the early patients because the trial protocol remains unchanged. Those patients were sure to be maintained beyond 1 year because of the incidental beneficial interim results.
2} Don't you find it compelling that 7 of the events came from the 18 SOC segment and only 5 from the 34 SOC + TNF side?