Replies to post #5078 on Dendreon Corp fka DNDNQ

[DownTheStretch]

Question on Gleason Score Dependence/Independence
Ranchero, Others,
Forgive my historical ignorance, but weren't the early favorable survival numbers based on a subset of Gleason scores (0-7).
Did I understand clearly that the final data will be for the entire Gleason spectrum (independent). Did the 2nd Phase data show the survival benefit was repeated for all Gleason scores?
I'm obviously confused about when we went from a Gleason subset to complete independence.

[iwfal]

My question was confusing since it ultimately asked about statistical significance, and meant to ask concerning the chances that at the interim, Vital 1 would be below a p value of 0.01.

That was the question I guestimated. (Although note that I left unstated a bunch of assumptions about enrollment curves, km curve shape, ... . But, heck, it was only a guestimate.)


From your answer, I am assuming that depending on curve shapes, etc, that percent power represents the chances or probability of both the treatment effect happening and being detected. Is that accurate?

No. See first answer above.

Will answer your second question later.