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EZLibra

09/28/07 8:49 AM

#17368 RE: jakedogman1 #17365

These make billions, see any names?

"A number of antiviral vaccine strategies have also been developed that make use of nonreplicating immunogens, including inactivated viruses, recombinant proteins, and virus-like particles (VLPs). Chemical treatment or irradiation of a virus can eliminate the ability of that virus to replicate while leaving it in a conformation that can present protective epitopes to cells of the immune system. The currently used hepatitis A vaccine is such an immunogen. Viral proteins expressed in cell lines can also be administered as immunogens. The hepatitis B vaccine is based on this approach. Finally, the recently developed papillomavirus vaccine is a VLP, an immunogen created through the expression of structural viral proteins that come together in vitro to form nonreplicating, noninfectious particles. The inactivated virus-, recombinant protein-, and VLP-based vaccines all induce antibody and CD4+ T lymphocyte responses because these immunogens undergo MHC class II processing. However, because they do not replicate in vivo, these vaccine antigens do not undergo MHC class I processing and therefore do not elicit CD8+ T lymphocyte responses."

Letvin is talking about the next generation of vaccines and it is looking more and more like Bavi is characterizing at least a part of it.

jazzbeerman

09/28/07 8:51 AM

#17369 RE: jakedogman1 #17365

jake,


What Letvin mentions as what is needed for an HIV vaccine to work, is what bavi does...


Coincidentally.... I spent yesterday posting on the importance of CD8+ T cells, how they get quickly depleted when infected, and how TGF-beta is responsible.

The TGF-beta comes from the (exposed PS due to the) massive apoptosis and shed microparticles caused by acute HIV infection.


Bavi (anti-PS) tips the scales of the cytokines away from TGF-beta, allowing dendritic cells to properly train those CD8+ T cells.

I'd suggest you read my posts of yesterday morning.

j