Replies to post #66901 on DNAprint Genomics (DNAG)

[frogdreaming]

Welcome back 'Hit and Run'.

As usual you lie in wait for months on end hoping to find an opportunity to pounce. lol

And as usual you have stepped in it again and will scurry off back into hiding after being handed your head.

Nevertheless it is nice to hear from you. I hope the summer is treating you and your family well, have a beer on me.

The function of introns is not known.

So you don't know if they 'code' or don't code? In fact you have no idea.

Such conserved nongenic sequences were recently proposed as additional regulatory elements (29). /b>

Meaning that they participate in the coding process.

Indeed, SNPs 2351, 2399, and 2949 alter putative binding sites for transcription factors TATA, MZF1 and P300, and SP1, respectively ..

For those following along at home the transcription factors are a part of the coding process.

Of these, SNP 2399 is predicted to abolish binding for MZF1 and P300 and SNP 2949 is predicted to abolish binding for SP1 transcription factors. Thus, this region might alter CASQ1 or perhaps PEA15 regulation and contribute to diabetes risk.

Again for those keeping score at home, CASQ1 and PEA15 are the expected result of the coding process, and any alteration of same is obviously a disruption of the coding process.

Here's the best part.

They don't have to "code" to impact protein synthesis. The authors are in fact suggesting that their effect may be through a "regulation" of the coding process itself.

Can you hear yourself? DO you not read what you write before you send it?

I thought you took a couple of Biology classes in your time. Do you not understand what nucleotides are?

Any single SNP is just one of four possible nucleotides that is 'exactly' the same as thousands and thousands of other identical nucleotides within the same sequence. It doesn't have a magic wand, it doesn't have super powers. It's only significance is it's position in the sequence. It's only ability to affect anything is the behavior of the 'coding' process when it encounters that particular sequence. It might create protein, it might code a disruption into the protein, it might terminate the protein prematurely, it might create a new and smaller 'regulatory' protein, it might do one of many things, but it will only do so by acting as an input to the coding process.

Now eat your lunch and get back into your ambush position. We will all look forward to hearing from you again.

regards,
frog