Replies to post #4961 on Insmed Inc (INSM)

[read_this_n0w]

INS-18 cancer indication still being researched:

2005:
Ira D. Goldfine, M.D. Professor of Medicine at UCSF will lead the investigative efforts with IGF-1 receptor antagonists to identify the compound with an ideal risk/benefit ratio to enter clinical trials. Working with Dr Goldfine at UCSF are: Drs Jack Youngren, Betty Maddux, Eric Small, and Charles Ryan, Department of Medicine; Dr John Kerner Department of Obstetrics and Gynecology; and Dr Michael Campbell, Department of Surgery. E[acute accent]Professor Goldfine commented, "This series of IGF-1 receptor antagonists are very interesting molecules that inhibit IGF-1 receptor activation, which can trigger tumorigenesis. These planned studies should allow us to identify another drug candidate to compliment our efforts with INSM-18 in the search for a treatment of prostate cancer."
http://findarticles.com/p/articles/mi_m0EIN/is_2005_March_17/ai_n13254240


2007:
This will be presented at the next ASCO meeting:

(...)Conclusions: NDGA attenuates androgen mediated tumor proliferation without direct antagonism of the AR. No DLTs have been observed in the first month of therapy. These results and modest effects on PSA kinetics in patients with non-metastatic rising PSA support further study in ADPC.

http://tinyurl.com/2hnstl

[wjlknew]

Rod,

Thanks for the information. I was surprised to learn the origin of "INSM-18". NDGA has the reputation for being a snake oil and has been effectively banned in the U.S. for some time. Over the years, it has been promoted to cure about everything, but some who ingested it developed serious kidney and liver problems ... some died I believe.

Now, Insmed has licensed the stuff to a questionable (to me at least) company for a variety of indications, making the deal public a couple of months later through an obscure paragraph in the 10-K. Combine that, the revised COC agreements being made public late on a Friday, the obviously scripted latest CC being cutoff before any probing questions could be taken, and I am reminded of the old saying: "Those who have nothing to hide, hide nothing".

On the other hand, .....