• Most of these drugs are nearing the end of their US patent protection.
• Januvia, Enbrel, Stelara, and Imbruvica are already in decline due to competition from newer and better drugs.
• For Eliquis, Xarelto, Jardiance, Farxiga, Januvia, and Novolog/Fiasp, the IRA prices are not hugely different from the prices of these drugs after existing rebates; for Entresto, Enbrel, Stelara, and Imbruvica, the IRA price cuts are steeper. See chart: