Replies to post #2116 on Dendreon Corp fka DNDNQ

[croumagnon]

9902a patients Vs 9901 patients

Anyone has an explanation as to why the 9902a patients enrolled were much sicker on the average than the 9901 patients enrolled? Other than East coast Vs West coast, I thought the criteria for enrollement were one and the same, so why this anomaly?

[Gametheory101]

Baseline bone lesion count > 10 was significantly imbalanced against the treatment arm in D9902a. That might have been the strongest factor contributing to the poor p value. So yes, adding a few more patients properly randomized would not have changed that imbalance enough to make a difference to the p value.

Doesn't this make the 9902a three year survival numbers of about 1/3 even more impressive?

Maybe the three year survival numbers for 9901 would have been higher if not for the large imbalance in non-prostate cancer specific death.