GTOP – It’s possible for efficacy metrics to improve over time even while K-M curves flatten out. On today’s CC, GTOP’s CEO tried to explain this to an abrasive shortseller who either didn’t get it or pretended not to.
Consider the make-believe K-M curves shown above, where red is the active arm and blue is the control arm. Between time points T1 and T2, the curves get flatter; however, the efficacy metrics could be better when measured after an elapsed time of T2 than when measured after an elapsed time of T1.