Thanks for this great information…
It won’t be long before Kraig’s technology becomes the envy of the world!!!
“In its US patent entitled Synthesis of High Molecular Weight Proteins Using Inteins, Kraig, headquartered in Ann Arbor, Michigan, reinvents its approach to manufacturing large-format spider silk protein with new technology allowing for the automated self-assembly of target proteins within the silkworm. The process allows for the opportunity to reach beyond the limits of current protein synthesis technologies.
This new approach, using the auto-processing capabilities of inteins – genetic elements that disrupt the coding sequence of genes – creates the opportunity to create plug-and-play blends of numerous spider silk proteins that are not inhibited by the current size limitation for targeted gene knock-in knock-out transformations.”
Sericin
The second patent, Synthesis of Non-Native Proteins in Bombyx Mori by Modifying Sericin Expression, moves beyond heavy chain fibroin and creates opportunities for the co-production of non-fibrous proteins within sericin. Sericin is the stick glue-like protein holding the silk fibres together, making up roughly 20% of the cocoon, and is broadly considered a waste product.
This invention seeks to leverage the untapped resource to increase the production of target proteins. Target materials include a range of possible applications, including therapeutic and pharmacological proteins. The current production systems for these proteins are inefficient and, therefore very expensive. This new process opens the possibility for large-scale production materials such as elastin, keratin, human collagen and many more at comparatively very low costs.
Our research team continues to deliver novel and innovative applications for our gene-editing technologies,” said COO Jon Rice. “While our production operations in Vietnam remain laser-focused on the large-scale commercial production of spider silk textiles, our lab is busy executing on the technology roadmap to secure our future and legacy.”
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