Replies to post #8377 on Halozyme Therapeutics Inc (HALO)

[Fred Kadiddlehopper]

Answering my own query using MS Copilot:

Me:
Query: is hyaluronan a component of muscle tissue in the same way it is in skin tissue?

Copilot
Certainly! Hyaluronan, also known as hyaluronic acid (HA), plays a significant role in both muscle tissue and skin tissue. Let’s explore how it functions in each context:

Muscle Tissue:
Hyaluronan is present in muscle tissue, constituting approximately 8% to 10% of the total HA in the body.
It is found within different layers of muscle tissue, including the endomysium, perimysium, and epimysium.
In muscle, hyaluronan serves several important purposes:

Lubrication: It acts as a lubricant, allowing smooth movement between muscle fibers during contraction.

Lateral Force Transmission: Hyaluronan facilitates force transmission laterally within muscle tissue during movement 1.

Antioxidant Properties: High-molecular-weight HA can neutralize free radicals and reduce inflammation and pain 1.

Skin Tissue:
Hyaluronan is well-known for its role in skin health.
It is a major component of the extracellular matrix in the skin.

Functions in skin include:

Hydration: Hyaluronan retains water, keeping the skin hydrated and plump.

Tissue Repair: It contributes to wound healing and tissue repair.

Viscoelastic Properties: Hyaluronan provides elasticity and resilience to the skin 23.

In summary, hyaluronan is essential for maintaining the health and function of both muscle and skin tissues, albeit in slightly different ways. Whether it’s supporting muscle movement or promoting skin hydration, this versatile molecule plays a crucial role throughout our bodies.

Learn more
1

onlinelibrary.wiley.com
2

hopkinsmedicine.org
3

webmd.com
4

my.clevelandclinic.org
+2 more

Me:
Query: is hyaluronan present in the same proportion of muscle tissue compared to skin tissue?

Copilot
Hyaluronan, also known as hyaluronic acid (HA), is present in both muscle tissue and skin tissue, but its proportion varies between the two:

Muscle Tissue:
Hyaluronan constitutes approximately 8% to 10% of the total HA in the body.
It is found within different layers of muscle tissue, including the endomysium, perimysium, and epimysium.
In muscle, hyaluronan serves several important purposes:
Lubrication: It acts as a lubricant, allowing smooth movement between muscle fibers during contraction.
Lateral Force Transmission: Hyaluronan facilitates force transmission laterally within muscle tissue during movement.
Skin Tissue:
Hyaluronan is a major component of the extracellular matrix in the skin.
Its functions in skin include:
Hydration: Hyaluronan retains water, keeping the skin hydrated and plump.
Tissue Repair: It contributes to wound healing and tissue repair.
Viscoelastic Properties: Hyaluronan provides elasticity and resilience to the skin.
Therefore, while hyaluronan is essential for both muscle and skin health, the proportion of its presence differs between these tissues .

Me:
What is the proportion of hyaluronan as a component of the extra cellular skin matrix
Copilot
Certainly! Hyaluronan, also known as hyaluronic acid (HA), is a critical component of the extracellular matrix (ECM) in the skin. Let’s explore its proportion and significance:

Amount of Hyaluronan in Skin:
In human skin, the epidermal ECM contains approximately 25 µg of HA per gram of fresh epidermis.
The dermis (deeper layer of skin) contains a higher amount of HA, ranging between 120 and 200 µg per gram of fresh dermis1.
Proportion in the Body:
Approximately 50% of the total HA in the body resides in the skin.
The turnover rate of HA in the skin is about 30%2.
Function in Skin:
Hyaluronan plays several crucial roles in skin health:
Hydration: It retains water, keeping the skin hydrated and plump.
Tissue Repair: It contributes to wound healing and tissue regeneration.
Viscoelastic Properties: HA provides elasticity and resilience to the skin.
In summary, hyaluronan is a vital component of the skin’s ECM, ensuring hydration, repair, and overall skin integrity. Its presence and functions are essential for maintaining healthy and youthful skin.