Levosimendan approved safe and effective for acute decompensated heart failure in 60+ countries since 2000 Intravenous levosimendan first treatment to show efficacy in PH-HFpEF in the Tenax Phase 2 trial FDA agreement to use oral levosimendan formulation in Phase 3 development program Discovery of levosimendan’s novel mechanism of action and treatment target makes it uniquely effective for HFpEF patients