Replies to post #435 on Aptose Biosciences Inc (APTO)

[Tartiaboy]

I agree APTO has put itself into a critical financial situation. That said they FINALLY have figured out that the key is combinations, especially with venetoclax. It looks like they now understand that that is the critical path forward. I am confident that as the dublet data evolves they will be reporting value driving data. This is what I have been waiting for (them to get into combinations). My plan is to slowly add shares over the next six months if things evolve as I expect.

I was happy to hear that they are now dosing Lux at 200 mg. That's a big jump from 50 mg. I believe that the current Lux plasma levels are high enough to see significant clinical activity IF they ever figure out to use LUX in combination with Venetoclax. They promised an update on Lux within several weeks. Could we get a surprise? Cross your fingers.

In summary. I think APTO is FINALLY on the right track. We jus need to navigate the financial crunch.

I do expect some partnership announcement(s) within the next six months.