If you look back to the March 2020 market panic you'll see that ENTA was essentially unaffected, and that was before the announcement of EDP-235. ENTA had already sold off considerably in 2019 for unrelated reasons. Impossible to say for sure what would happen in a future hypothetical panic but it's not unprecedented that ENTA could be spared, especially after this year's already brutal sell off.
So that was early August. I'm not making a call or time stamping anything because there has been "a recession coming in the next 6-9 months" for at least a year and a half. The market can still make new highs from here. It just continues to look right to be cautious.
$XBI is probably going to have another losing year. There should be plenty of tax loss selling over the next 2-3 months. Not sure how many of those names are worth looking at but a few should have outsized gains to start next year. I've looked at some screens of potential names and it's not as attractive as in past years.