I guess this news explains your return from a 3 year hiatus to make a few points, some of which I agree with. "Your start with relatively health people " No, you start with HEALTHY people in the Phase 1a.
"Phase II will expand the demographics." Not necessarily. If there is a Phase 2 it will recruit a much larger group of patients and they won't be healthy.
My questions related to sample sizes, inclusion/exclusion criteria and fuzzy language. I thought they were decent questions and I know there's at least one person here who can either address them or tell me they're inconsequential. I think that would better be done BEFORE all the positive outcomes are revealed since the answers may have a bearing on how those outcomes are interpreted.