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williamssc

06/09/23 5:18 PM

#398185 RE: PJ007 #398181

Bril disrupts the cell wall and this action coupled with fungistatic CAS make a fungicide. So both given together they have a fungicidal killer. Sounds huge.

"Taken together, BRI acts by impacting A. fumigatus calcineurin signaling and the cell wall integrity pathway converting the fungistatic action of CAS against A. fumigatus into a fungicidal drug".