Replies to post #287 on AstraZeneca PLC (AZN)

[jondoeuk]

The company has inked a non-exclusive licensing deal with Revvity to use its Pin-point base editing platform in the development of new cell therapy treatments for cancer and other immune-mediated diseases. Pin-point uses a novel three-part design with an RNA aptamer guide, a modified Cas9 enzyme and a deaminase enzyme.

The platform is highly efficient and precise, allowing for multiplex editing with >75% editing in each target base. Also, has a strong safety profile with negligible off-target edits and no translocations. In addition, has no impact on cell health and allows for one-step complex engineering, which is simultaneous multiple knock-ins and knockouts (at least seven).

[jondoeuk]

Next into the clinic should be this https://aacrjournals.org/cancerres/article/83/8_Supplement/LB085/725614/Abstract-LB085-Antitumor-activity-of-AZD0754-a

Also, a trial testing an CLDN18.2-targted version with the same dnTGFbRII armour is planned.

The first TCR-T therapy https://clinicaltrials.gov/ct2/show/NCT05877599 that is armoured as well http://www.neogene.com/staging/wp-content/uploads/2022/04/Keystone-2022-TGFBR2-KO-TP53-R175H-TCR-poster-final-edit.pdf

They have been working on additional edits https://jitc.bmj.com/content/10/Suppl_2/A253