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Replies to post #257932 on Kraig Biocraft Laboratories Inc (KBLB)
04/06/23 8:57 AM
04/06/23 9:20 AM
Methods and compositions for synthesizing improved silk fibers
Patent number: 11505654
Abstract: The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
Type: Grant
Filed: June 22, 2018
Date of Patent: November 22, 2022
Assignee: BOLT THREADS, INC.
Inventors: Daniel M. Widmaier, David N. Breslauer, Joshua Kittleson, Brendan Turner, Lindsay Wray
Long uniform recombinant protein fibers
Patent number: 11447532
Abstract: The present disclosure provides improved long uniform recombinant protein fibers with desirable physical traits. The present disclosure also provides compositions derived from the long uniform recombinant protein fibers.
Type: Grant
Filed: September 14, 2017
Date of Patent: September 20, 2022
Assignee: BOLT THREADS, INC.
Inventors: David Breslauer, Joshua Kittleson, Loren Perelman, Lindsay Wray
Compositions and methods for producing high secreted yields of recombinant proteins
Patent number: 11306127
Abstract: The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the present disclosure relates to methods for producing high secreted yields of recombinant proteins, and the compositions provided herein include expression constructs, recombinant vectors, and recombinant host cells that comprise polynucleotide sequences encoding proteins operably linked to recombinant secretion signals that comprise the leader peptide of the -mating factor (MF) of Saccharomyces cerevisiae and a non-MF signal peptide.
Type: Grant
Filed: March 13, 2018
Date of Patent: April 19, 2022
Assignee: Bolt Threads, Inc.
Inventors: Joshua Kittleson, Thomas Stevens, Rena Hill, Carlos Gustavo Pesce, David N. Breslauer, Daniel M. Widmaier
Modified strains for the production of recombinant silk
Patent number: 11214785
Abstract: Disclosed herein are modified strains for reducing degradation of recombinantly expressed products secreted from a host organism and methods of using the modified strains. In some embodiments, to attenuate a protease activity in Pichia pastoris, the genes encoding enzymes the degrade proteases are inactivated or mutated to reduce or eliminate activity. In preferred strains, the protease activity of proteases encoded by PAS_chr4_0584 (YPS1-1) and PAS_chr3_1157 (YPS1-2) (e.g., polypeptides comprising SEQ ID NO: 66 and 67) is attenuated.
Type: Grant
Filed: April 7, 2020
Date of Patent: January 4, 2022
Assignee: Bolt Threads, Inc.
Inventors: Matthew Scott Gamboa, Joshua Tyler Kittleson
Methods of generating highly-crystalline recombinant spider silk protein fibers
Patent number: 11208736
Abstract: Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.
Type: Grant
Filed: September 25, 2018
Date of Patent: December 28, 2021
Assignee: Bolt Threads, Inc.
Inventors: Amir Ahmad Bakhtiary Davijani, Steven Tom, Maxime Boulet-Audet, Paul Andre Guerette, Lindsay Wray, Nicole Elizabeth Subler, Zoya Nasir Zulfiqar, Hua Li, Jessica Wang
Methods and compositions for synthesizing improved silk fibers
Patent number: 11192982
Abstract: The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
Type: Grant
Filed: August 30, 2019
Date of Patent: December 7, 2021
Assignee: Bolt Threads, Inc.
Inventors: Daniel M. Widmaier, David N. Breslauer, Joshua Kittleson, Brendan Turner, Lindsay Wray
No one is saying they will. But the DOD will grant them funding. The USAF specifically asked for spider silk. What other U.S. company can fulfill that request?
No one is saying they will. But the DOD will grant them funding. The USAF specifically asked for spider silk. What other U.S. company can fulfill that request?
04/09/23 11:48 PM
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