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dloggold

11/29/22 11:56 AM

#37862 RE: eb0783 #37861

the only way it would make any sense would be having any degree of an immune system malfunction where the vaccine alone is dangerous i suppose?
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cowtown jay

11/30/22 11:05 AM

#37868 RE: eb0783 #37861

I've appreciated the discussion regarding Humanigen's latest patent, which includes a second drug consisting of an anti-viral, a vaccine, and polyclonal antibodies.

I particularly want to note dlog's point that it makes no sense to take a vaccine, if you already have covid.

So I have done some additional research, and I have concluded that our second drug compound, with the vaccine component, may not be intended for patients with covid after all. Rather, I think this second drug may be intended as a postexposure prophylaxis (PEP), especially for vulnerable patients domiciled with infected members of the household.

And perhaps surprisingly, studies have shown that there may be a favorable cost benefit.

"April 22, 2022
Estimated Health Outcomes and Costs of COVID-19 Prophylaxis With Monoclonal Antibodies Among Unvaccinated Household Contacts in the US

...Conclusions and Relevance

In this modeling study of a simulated US population, a mAb PEP for COVID-19 program was estimated to improve health outcomes and reduce costs. In the setting of a susceptible variant of SARS-CoV-2, health system and public health actors would have an opportunity to improve health and reduce net payer costs through COVID-19 PEP with mAbs..."

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2791451?guestAccessKey=416d0ebf-58bc-4e2e-8e5f-e1cdd0bb0545&utm_source=silverchair&utm_campaign=jama_network&utm_content=covid_weekly_highlights&utm_medium=email

“Promising advances in efforts to isolate and develop mAbs with activity against a broad range of sarbecoviruses could lessen the risk of loss of activity with future SARS-CoV-2 genotypes/variants,” the study authors noted.

One variant-agnostic therapy currently under development is Humanigen’s monoclonal antibody lenzilumab, which showed promise for treating hyperinflammatory response to SARS-CoV-2 infection in recently published phase 3 trials."

https://www.contagionlive.com/view/monoclonal-antibodies-for-post-exposure-prophylaxis-could-saves-lives-and-money

This concerns the REGEN-COV study platform.

I need to further study the data, but this is exactly the type of large scale platform Durrant has mentioned to advance lenz.