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Cyosol

10/06/22 7:30 PM

#20316 RE: HANUMAN #20315

They measured a group of people with amyloid beta in their brains, with specific genetic variants that increase the risk of getting AD, and found that the patients that declined over time had less soluble amyloid beta in their brain than the patients that remained normal.

So the basic gist of it is that they're debunking the theory that amyloid is toxic and destroying the brain, because if it is toxic you would expect declining patients to have more of it in their brain than the patients that retain normal cognition, and yet the opposite is true.

So is the cause of AD just a lack of soluble amyloid beta in the brain? Of course not, but the authors say you could predict how a patient with amyloid in their brain and these specific genetic variants is going to progress based on the amount of soluble abeta in their brain.

Correlation =/= Causation