improve in vivo effectiveness in the form of a nasally-delivered countermeasure
They haven't put the stuff in the noses of any living things yet, have they?
I would hope they have some baseline data in order to alter dosing strategies to improve effectiveness. That would lead me to believe they've sprayed a mouse or ten with the stuff. Why not?
Head to the dollar store to get a spray bottle, grab some 10 for $10 mice at the pet store, mix in a little Brilacidin powder from last year's science fair, and BAM! In vivo results!
I'm not holding out much hope on this one. We've seen what IPIX in vivo studies are worth.
Indeed, much should be made of ongoing efforts focused on dosing strategies for brilacidin to improve in vivo effectiveness in the form of a nasally-delivered anti-viral, anti-inflammatory early treatment. It's very different from Brilacidin being delivered by IV in moderate and severely ill hospitalized patients.