Here's the kicker. The discussion is moot. If CYDY was worried about effectiveness, they wouldn't have included this part in the S-3.
They are able to subsequently file an amendment removing this language and stating that the S-3 will be effective 20 days later according to the Securities Act Section 8(a).
There's no "16:30 on a Friday" deadline here. Where does that stuff come from?
Right now, the SEC has 20 days to declare effectiveness or state why the registration isn't effective.