Replies to post #904 on Genocea Biosciences Inc (GNCAQ)

[jondoeuk]

From this: ''Using high-dimensional analysis of human ACT products, we identified a memory-progenitor CD39-negative stem-like phenotype (CD39-CD69-) associated with complete cancer regression and TIL persistence and a terminally differentiated CD39-positive state (CD39+CD69+) associated with poor TIL persistence.'' https://www.science.org/doi/10.1126/science.abb9847

Also, ''With a median potential follow-up of 89 months, 46 of 48 complete responders in the aPD-1-naïve cohort have ongoing responses after a single treatment and 10-year melanoma-specific survival of 96%.'' https://aacrjournals.org/clincancerres/article-abstract/27/19/5289/671696/Impact-of-Prior-Treatment-on-the-Efficacy-of

Hopefully, a trial testing these double negative TIL in melanoma, as well as other types will be underway soon.