A SARS-CoV-2 Wuhan spike virosome vaccine induces superior neutralization breadth compared to one using the Beta spike Yme U. van der Velden, Marloes Grobben, Tom G. Caniels, Judith A. Burger, Meliawati Poniman, Melissa Oomen, Esther Siteur-van Rijnstra, Khadija Tejjani, Denise Guerra, Ronald Kempers, Toon Stegmann, Marit J. van Gils & Rogier W. Sanders
Our results show that Beta spike vaccination induces inferior neutralization breadth. These results are informative for programs aimed to develop broadly active SARS-CoV-2 vaccines.