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Lemoncat

02/14/22 9:58 PM

#388185 RE: Empiricst1 #388167

Of course a pill would be better, but that just does not exist yet, as we have seen;



This issue is that a phase 2 oral B-UC could be very quick and cheap. It's probably the biggest potential we could run with cash on hand. If it fails, AS can move ahead with the enema. Until it does, they aren't going to waste money on a phase 3 that will be obsoleted by our B-UC pill.


an injection would probably be even better (at least re development, I would think)



I don't think so. One of the good findings about the B-OM, B-UC, and B-UP trials is that high doses of B can be delivered throughout the digestive tract with negligible absorption into the blood stream. B in the blood stream is where the side effects start to show up.

but did see that their 2021 estimates were for completed tests of B by 2023 or 2024



Well, we're in 2022 and as far a we know they haven't even started a phase 2 yet. Say they complete that by mid 2023 and then start a phase 3 in early 2024. It will likely run to mid 2025 which is when we could expect the second $1M payment IF endpoints are met. NDA takes a year so maybe it would be on the market at the start of 2027?