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Replies to post #241294 on Biotech Values
01/24/22 10:22 AM
03/10/22 4:55 PM
05/12/22 5:21 PM
05/24/22 5:27 PM
06/21/22 2:01 PM
Assembly Biosciences…plans to host a webcast on Tuesday, July 26, 2022 from 1:30-2:30 pm PT/4:30-5:30 pm ET to introduce its new research program advancing a novel, small molecule interferon-alpha receptor (IFNAR) agonist designed to selectively activate the interferon-alpha pathway within the liver and offer the convenience of oral dosing.
07/20/22 4:57 PM
Assembly Biosciences will discontinue clinical development of its first-generation investigational core inhibitor, VBR, based on review of interim on-treatment efficacy from the two ongoing VBR triple combination studies. The data indicate that the triple combinations do not show a benefit in multiple key viral parameters compared to the dual combinations without VBR in either study.
…As a result of these data, Study 203, an open-label, Phase 2 study evaluating the triple combination of VBR + nucleos(t)ide analogue reverse transcriptase inhibitors (NrtI) + interferon (PEG-IFN-alpha) versus the dual combinations of VBR + NrtI and NrtI + PEG-IFN-alpha, will conclude immediately.
No additional clinical studies of VBR are currently planned.
[ASMB’s] first HBV core inhibitor, VBR (f/k/a ABI-H0731), failed in a 2-drug combination with a nucleoside (#msg-159327881) and is now in various combination trials with external agents (#msg-157913492, #msg-166413748). These trials have a low chance of success (IMO) because VBR is a weak agent on its own, so there would need to be an astonishing degree of synergy for such combinations to provide a functional cure for HBV (the goal that all HBV companies are pursuing). All told, the VBR program looks like an example of Zebra’s Law.
10/05/22 4:58 PM
03/22/23 5:16 PM
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