Replies to post #382360 on Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

1U of heparin = .002mg

https://www.itwreagents.com/download_file/product_infos/A3004/en/A3004_en.pdf

Therapeutic serum level of heparin is .4U to .7U

https://pubmed.ncbi.nlm.nih.gov/8512158/

In the Caco-2 cells and the Calu 3 human cell lines the heparin effect seems to begin at about 3ug to 10ug/ml

https://www.biorxiv.org/content/10.1101/2021.11.04.467344v1.full.pdf

graph G,H and I


.7U of heparin = .0014 mg = 1.4 microgram

Therefore the upper limit of serum heparin should have no effect on Brilacidin against Covid

Good luck to all,

Farrell

[cellardwellar]

Delgrado never used the term significantly reduce.

Brilacidin partially loses its antiviral activity when heparin was included in the cell cultures, supporting the host-targeting mechanism. Drug combination therapy showed that brilacidin has a strong synergistic effect with remdesivir against HCoV-OC43 in cell culture.