Yes but when they added the criteria for CRP <150, there were less then 200 patients enrolled. So if now we are enrolling 500pt, we can assumed that at minimum the new 300 pt will have CRP < 150. And, for the first 200 patients at least some of them will also have this criteria. In hgen trial they reached with 300ish pt an pvalue of 0.003, why do you thing that now they cannot reach stat sig ?
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