For anyone wondering where the relevant information concerning leronlimab is within this document, go to page 13 and read under the emerging treatments section.
Here's the excerpt:
Other potential treatments are molecules that suppress the intense inflammatory response seen in covid-19. Leronlimab is a monoclonal antibody that blocks the function of CCL-5. It has been shown to be effective and safe in HIV213 and reduces plasma interleukin-6 levels in covid-19.214 Clinical trials are ongoing to evaluate the efficacy of leronlimab post-covid-19 (NCT04343651, NCT04347239, NCT04678830).
Here are the referenced resource materials:
213
Dhody K, Pourhassan N, Kazempour K, et al. PRO 140, a monoclonal antibody targeting CCR5, as a long-acting, single-agent maintenance therapy for HIV-1 infection. HIV Clin Trials 2018;19:85-93. doi:10.10 80/15284336.2018.1452842
214
Patterson BK, Seethamraju H, Dhody K, et al. CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14. Int J Infect Dis 2021;103:25-32. doi:10.1016/j. ijid.2020.10.101