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Replies to post #47364 on Franklin, Andrews, Kramer & Edelstein

Replies to #47364 on Franklin, Andrews, Kramer & Edelstein
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scion

07/24/21 7:26 AM

#47365 RE: scion #47364

Cognitive deficits in people who have recovered from COVID-19

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00324-2/fulltext#seccesectitle0013

Abstract

Background
There is growing concern about possible cognitive consequences of COVID-19, with reports of ‘Long COVID’ symptoms persisting into the chronic phase and case studies revealing neurological problems in severely affected patients. However, there is little information regarding the nature and broader prevalence of cognitive problems post-infection or across the full spread of disease severity.

Methods
We sought to confirm whether there was an association between cross-sectional cognitive performance data from 81,337 participants who between January and December 2020 undertook a clinically validated web-optimized assessment as part of the Great British Intelligence Test, and questionnaire items capturing self-report of suspected and confirmed COVID-19 infection and respiratory symptoms.

Findings
People who had recovered from COVID-19, including those no longer reporting symptoms, exhibited significant cognitive deficits versus controls when controlling for age, gender, education level, income, racial-ethnic group, pre-existing medical disorders, tiredness, depression and anxiety. The deficits were of substantial effect size for people who had been hospitalised (N = 192), but also for non-hospitalised cases who had biological confirmation of COVID-19 infection (N = 326). Analysing markers of premorbid intelligence did not support these differences being present prior to infection. Finer grained analysis of performance across sub-tests supported the hypothesis that COVID-19 has a multi-domain impact on human cognition.

Interpretation
Interpretation. These results accord with reports of ‘Long Covid’ cognitive symptoms that persist into the early-chronic phase. They should act as a clarion call for further research with longitudinal and neuroimaging cohorts to plot recovery trajectories and identify the biological basis of cognitive deficits in SARS-COV-2 survivors.

Funding
Funding. AH is supported by the UK Dementia Research Institute Care Research and Technology Centre and Biomedical Research Centre at Imperial College London. WT is supported by the EPSRC Centre for Doctoral Training in Neurotechnology. SRC is funded by a Wellcome Trust Clinical Fellowship 110,049/Z/15/Z. JMB is supported by Medical Research Council (MR/N013700/1). MAM, SCRW and PJH are, in part, supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
Keywords
COVID-19
Long covid
Cognition
Deficits
Online assessment
Attention
Memory
Reasoning
Planning

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00324-2/fulltext#seccesectitle0013
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scion

07/24/21 7:40 AM

#47366 RE: scion #47364

Prof. Christina Pagel @chrischirp See also this study in macaques with covid showing all developed what are called Lewy bodies associated with Parkinson's.

1918 flu also associated with Parkinson's years later.

We are risking *a lot* by ignoring mass infection.


Prof. Christina Pagel
@chrischirp
· 13h
LONG COVID THREAD:

The people running the BBC Horizon "Great British Intelligence Test" challenge on over 80,000 people took the opportunity to see if they could detect any differences by whether people had had covid or not...
Show this thread


7:54 AM · Jul 24, 2021·Twitter for Android

THREAD