Replies to post #366373 on Innovation Pharmaceuticals Inc (IPIX)

[olden_grumpini]

Brilacidin can absolutely be developed as a prophylactic in addition to a therapeutic. PolyMedix was developing a prophylactic product called PolyCide® for, among other uses, antimicrobial sutures. Here's a quote from a 2011 article (PolyMedix Presents Data Showing Antimicrobial Activity of Sutures Containing PolyCide):

The PolyCide materials, like PolyMedix’s antibiotic PMX-30063 which is currently in a Phase 2 clinical trial for the treatment of Staphylococcus infections, are synthetic mimetics of the host-defense proteins, and employ the same mechanism of action that directly and selectively targets and disrupts the bacterial cell membrane. Host defense proteins represent one of the oldest and most effective antimicrobial defense systems found in humans and virtually all living creatures.

This research was supported by a grant PolyMedix received from the National Science Foundation to support the development of antimicrobial sutures (NSF SBIR Award 1013835).

IPIX is not pursuing brilacidin as a prophylactic. I don't fault them at all. I would be doing the same thing. IPIX is all-in on brilacidin as a therapeutic.