HEPA CRV431 in Nash Phase 2A Preliminary Conclusions:
1. Reduction transaminases at 28 days what MDGL took 3 months to achieve signals early efficacy for HEPA CRV431 in F2/F3 Nash subjects.
2. HEPA CRV431 predicts reductions in serum alanine transaminase.
3. Trial simulations with HEPA's AIPOWR platform predict & suggest greater efficacy at 150mg and 225mg dose levels!
4. Bioinformatics with AI-POWR trademarked reveal reveal significant interactions with with collagen regulating genes.
5. Confirmation of these effects will be fully evaluated using the 225mg cohort and the final genomic & lipidomic, and biomarker data for a full simulation of the Phase2b Trial for NASH.