Panning out fine??!! It's failed twice already, changing the trial after the first failure is somewhat understandable but the second time is a hail mary.
It didn't fail twice. It has changed its primary endpoint twice. The DSMC only allows a trial to change its primary endpoint if they believe the trial is showing promise. It is a good thing, not a bad thing.
Results from HGEN's interim analysis explained in the below link. And remember, the 37% efficacy that lenzilumab demonstrated is the whole trial, not a 62 patient slice.