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bow-tie

03/26/21 10:55 PM

#23915 RE: bow-tie #23914

From Last post: Used Virosomes instead of Alum :) Merck never use Alum again!!

Correlation between mouse potency and in vitro relative potency for human papillomavirus Type 16 virus-like particles and Gardasil vaccine samples

Correlation between mouse potency and in vitro relative ...
pubmed.ncbi.nlm.nih.gov › 17012876
1 Merck Research Laboratories Department of Bioprocess & Bioanalytical Research, West Point, Pennsylvania, USA. Mary_Retzlaff@merck.com ... Virosomes Substances Human ...

https://pubmed.ncbi.nlm.nih.gov/17012876/


Virus-like particles (VLPs) are an effective means of establishing both prophylactic and therapeutic immunity against their source virus or heterologous antigens. The particulate nature and repetitive structure of VLPs makes them ideal for stimulating potent immune responses. Epitopes delivered by VLPs can be presented on MHC-II for stimulation of a humoral immune response, or cross-presented onto MHC-I leading to cell-mediated immunity. VLPs as particulate subunit vaccine carriers are showing promise in preclinical and clinical trials for the treatment of many conditions including cancer, autoimmunity, allergies and addiction. Supporting the delivery of almost any form of antigenic material, VLPs are ideal candidate vectors for development of future vaccines.
https://www.future-science.com/doi/10.4155/tde.14.74