Replies to post #352753 on Innovation Pharmaceuticals Inc (IPIX)

[frenchbroad]

Brilacidin will soon enter the Fast course of the Track. Merci en avance to the US FDA. For now Ipix just conserve speed and collect data. When 3rd gear is engage our head will fly backward. Bonne chance to you M Farrell.

[steelyeye]

Excellent, and well stated...

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=162684861

[sunspotter]

You’re probably going to get remdesivir if you were entered into the brilacidin trial in the US anyway. Along with steroids it’s considered standard of care in many US centers. Let’s hope it doesn’t interact with brilacidin in any adverse way.

[LilyGDog]

Awesome post farrell90!!!

Go Leo & IPIX!

If I am seriously ill with Covid19 and go elsewhere there is almost a 100% chance of receiving Remdesivir which has been shown to have next to no effect on mortality or Covid complications.

Plus, we know Rememdesivir has been shown to have the potential to have hepatotoxicity since the current dose is close to the safe theraputic index...a ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective.

The hepatotoxicity was first described in the Ebola studies and is now being reported in Covid 19 patients being treated with Remdesivir.

Below are several recent reports of Covid19 patients suffering liver damage due to Remdesivir.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386240/

"Our observation supports previous findings obtained in healthy volunteers (Gilead Sciences, data on file) and COVID-19 patients treated with RDV [4, 5], suggesting this antiviral may cause hepatocellular injury."

In addition Remdesivir has many drug interactions which can limit treatment of other life threatening conditions:

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa883/5864408

https://www.uptodate.com/contents/image/print?imageKey=EM%2F73326&topicKey=RHEUM%2F1666&source=see_link

Your contention that Brilacidin may have "known Serious Adverse Events" pales to the risk of Remdesivir. If a patients on Brilacidins blood pressure increases it is easily treatable and serious elevations of blood pressure were not demonstrated at the Brilacidin.6mg/kg dose. The tingling sensation has not been shown to be associated with neurologic or other long term complications.

The real question is would you rather have a drug with the potential to have profound effect against the Covid19 or a drug we know has little effect.

I will stand by my post.

My bet is after Brilacidins Phase2 trial there will be many requests across the country for compassionate use of Brilacidin for Covid 19 for the reasons I have outlined.

GLTA Farrell