Replies to post #351168 on Innovation Pharmaceuticals Inc (IPIX)

[Jhawker]

I think he does realize that what he is saying is the opposite!

[MinnieM]

The slide in discussion is #18 in this presentation from 2015 for the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2015): “A Randomized, Double-Blind Study Comparing Single-Dose and Short-Course Brilacidin

https://static1.squarespace.com/static/5715352e20c647639137f992/t/583f8286d2b85731b8713a36/1480557192947/A-Randomized-Double-Blind-Study-Comparing-Single-Dose-and-Short-Course-Brilacidin-to-Daptomycin-in-the-Treatment-of-Acute-Bacterial-Skin-Skin-Structure-Infections-ABSSSI1.pdf

The circling was already on the presentation. But, I agree with your assessment that

a drug like brilacidin that *might* raise your BP some would not necessarily be a bad thing in this situation.

Message in reply to:

You do realize the items you circled show the opposite of what you claim, right?

The single 0.6 mg/kg brilacidin dose had lower frequency of adverse events for hypertension compared to SOC / daptomycin.

Maybe try again, and circle the ones showing brilacidin had a higher rate of mild hypertension? I would recommend circling the 3-day brilacidin dose, since that is highest incidence of mild hypertension, and that is what we will be using in our trial.

We don't know the comparison dose for Covid, but 0.6 mg/kg x3 days makes sense.

Some sick Covid patients are on pressors to RAISE their BP, so having a drug like brilacidin that *might* raise your BP some would not necessarily be a bad thing in this situation.

[loanranger]

"You do realize the items you circled show the opposite of what you claim, right?"

The circles are part of the original document...they weren't added.