I am completely befuddled with your statement that the odds for Brilacidin having successful trials are "high, high".
In all the expected trials, CV included, Brilacidin is being tested at dosages below, or equal, to those given in prior trials where no safety issues were encountered. So why would one expect safety problems now?
In terms of efficacy, especially for CV, with an SI of 426 how can one expect anything but success with an extremely high level of confidence? If it doesn't do great, than the SI used by medicine is an absolute joke and doesn't mean squat. So are you saying you think the SI is just pure BS?
Is there risk, yes, but "high, high" risk? In my opinion, no.
I know we differ in viewpoint and I respect yours, but I tend to believe you are viewing Brilacidin as the same kind of drug you have seen tested in years past where they really didn't know squat about it prior to the trials. The many years of using computational screening IMO makes Brilacidin a whole new animal of drug.
Kind of like the recent landing on Mars, could this have been done years ago without the computer power we now possess to limit the odds of failure? Same thing with our drug compared to prior drugs.
Hope I am right on this subject so we both succeed in our investment.
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