CRP has the best AUC (Area Under the Curve) of all single predictors of risk. Even better than age or comorbidities. Age comes second. I already posted the link to the research paper that demonstrated this. The reason Cytodyn’s trial excludes high-risk patient is not related to CRP but to CD12’s inclusion criteria number 3. I already posted about that. My point about CRP was to prove that Toci’s study excluded low-risk patients. Hence why you see non ventilated patients yet a high mortality. Because CRP is good at finding the ones truely at risk.
Correlations between positive risk predictors is entirely normal in supervised learning. It’s pretty usual. Yet, CRP remains the purest “signal” of all.
Last, we would all know by now if Leronlimab had helped reduce mortality. And this Leronlimab failure is statistically fully consistent with all the research papers I refered to in the past.
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