For Someone who claims to have done a lot of reading and comes up with that number is a complete SMH big time lol. I’ve done a lot of reading and my prediction is a SOLID %95 chance of success. Probably 99 imo. ADVA-27A is always compared to Etoposide. Etoposide is the leading cancer drug in use today that’s approved through FDA, and our drug is 16x more effective and has since improved massively.
“”Google Etoposide and compare””
....do some real DD
Etoposide - IC50.... 59.2
ADVA-27A -IC50.... 1.4.... this is a HUGE difference!!!
WIKIPEDIA.....
—Etoposide (VP-16) is the first agent recognized as a topoisomerase II inhibitor of anticancer drug with IC50 of 59.2 µM. ... The IC50 values of etoposide against the tumor cell lines
—Adva-27a is an excellent inhibitor of Topoisomerase II with an IC50 of only 13.7 micromolar (this number has recently been reduce to 1.44 micromolar as a result of resolving the two isomeric forms of Adva-27a
Adva-27a...clearance is nontoxic in humans .
“Adva-27a has excellent clearance time (half-life = 54 minutes) as indicated by human microsomes stability studies and pharmacokinetics data in rats.
Adva-27a clearance is independent of Cytochrome P450, a mechanism that is less likely to produce toxic intermediates.
Adva-27a is an excellent inhibitor of Topoisomerase II with an IC50 of only 13.7 micromolar (this number has recently been reduce to 1.44 micromolar as a result of resolving the two isomeric forms of Adva-27a).
Adva-27a has shown excellent pharmacokinetics profile as indicated by studies done in rats.
Adva-27a does not inhibit tubulin assembly.”
To do a lot of reading and post a number like %5? .... perfect example of why no one should believe anything without doing their own reliable DD!!!!!!
ADVA-27A....DESTROYS CANCER!!
Adva-27a Anticancer Drug
Adva-27a, a small molecule that has been shown to be exceptionally effective at destroying Multidrug Resistant Cancer Cells,
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