Replies to post #28239 on Pressure Biosciences Inc (PBIO)

[Anita Dump]

SinuSys reports that chronic sinusitis affects more than 31 million people in the United States and that it is more prevalent than heart disease or asthma and has a greater impact on patients' quality of life than chronic back pain or congestive heart failure. The majority of patients with chronic sinusitis are treated with oral antibiotics and/or nasal steroids, which can increase the risk of antibiotic resistance and cause unwanted side effects such as nose bleeds, nasal ulcers, and nasal and oral infections. The most effective sinusitis treatment is Functional Endoscopic Sinus Surgery (FESS) with rapid balloon dilation at high pressures, which is known to cause significant patient discomfort and is conducted in a surgical suite under general anesthesia or IV sedation. Annually, it is estimated that $11 billion is spent in the U.S. alone on improving the health of patients with sinus conditions.

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Mr. Schreck explained: "In the post-FESS patient population, drug-eluting spacers or stents are typically inserted into the surgically revised sinus opening to deliver steroids locally for reduction of inflammation, scarring and adhesions. Traditional spacers or stents are designed to slowly degrade and be bio-absorbed in place, but their polymer scaffolds can degrade unevenly, causing inflammation and requiring surgical removal of remnants and damaged tissue. Our lead product candidate Restora infuses the desired steroid via a bio-inert and non-inflammatory matrix material that is long-proven with exemplary safety profiles in humans, and that is simply and painlessly inserted and then fully removed by the physician after treatment."

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"Our patented UST platform is a unique breakthrough for nanoemulsification processing designed to resolve multiple substantive problems facing manufacturers of therapeutic drugs, nutraceuticals, and other products containing hydrophobic (water repelling) active ingredients that are at best poorly soluble in water. Poor water solubility results in lower absorption rates and requires much higher loading of the active compounds into products to achieve targeted dosing and bioavailability of active ingredients for the patient. Unfortunately, poor water solubility also carries overdosing risks in conventional emulsions due to oil and water phases further separating and leading to non-uniform drug distribution. Scientific publications have demonstrated that hydrophobic active ingredients manufactured into high quality nanoemulsions with droplet sizes of less than 100 nanometers can facilitate increased absorption and bioavailability while lowering doses and improving controlled release. This should result in better quality products and treatment experiences for the patient, with overall reduction in product costs."

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Great news for $PBIO

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"We believe the therapeutics applications for our uniquely enabling UST nanoemulsions technology platform will be transformational across a wide swath of pharmaceutical, biopharmaceutical, nutraceutical, cosmeceutical, dermatological, medical device, and many other applications and markets. We are at an exciting moment in PBI's development when our new, proprietary UST technology platform is soon to be commercially released (mid to late 2021) and initial collaborations are being both announced and commenced. We have recently been approached by several other companies with therapeutics applications. We anticipate multiple additional collaboration and licensing announcements soon, all of which we believe could add significantly to our revenue in 2021, and beyond."

[Anita Dump]

"Our patented UST platform is a unique breakthrough for nanoemulsification processing designed to resolve multiple substantive problems facing manufacturers of therapeutic drugs, nutraceuticals, and other products containing hydrophobic (water repelling) active ingredients that are at best poorly soluble in water. Poor water solubility results in lower absorption rates and requires much higher loading of the active compounds into products to achieve targeted dosing and bioavailability of active ingredients for the patient. Unfortunately, poor water solubility also carries overdosing risks in conventional emulsions due to oil and water phases further separating and leading to non-uniform drug distribution. Scientific publications have demonstrated that hydrophobic active ingredients manufactured into high quality nanoemulsions with droplet sizes of less than 100 nanometers can facilitate increased absorption and bioavailability while lowering doses and improving controlled release. This should result in better quality products and treatment experiences for the patient, with overall reduction in product costs."