Replies to post #201 on Idenix Pharmaceuticals (IDIX)

[go seek]

no knowledge of Globeimmune, rsox

regards,

[dewophile]

"after many years of treating her they are suggesting this study"

Am I to infer then that your mom is treatment-refractory? what genotype?

If she has already failed tx and is in good health you might want to look into getting her enrolled in PROVE-3..I'm not a hep doc, but I think if I had such a profile I'd go for vx-950 over a very early stage "therapeutic vaccine" trial

alternatively if she is tx-naive, especially non-gen-1, why not just go for SOC

if there is some contraindication to interferon and/or rib and there is some pressing reason to treat like advancing fibrosis, then this study may make sense..or if she has stable disease and just wants to take a stab at a non-interferon-based therapy for a "cure"

I would really ask the doc the rationale for this study over other options in her particular case
just my lay opinion - take it for what its worth (which may not be much!)

[gofishmarko]

Re : Globeimmune trial

Like dewophile I would think the Prove 3 trial would offer a better chance of a successful outcome , though I don't know much about GI-5005 and Schiff presumably does.

One thing to look at to help you decide -- the enrollment rates of the trials , as a means to weigh the perceptions of the medical / patient community about the tx. in question. VRTX will enroll hundreds of patients for Prove 3 in a matter of months , while it looks like the Globeimmune trial has been enrolling since '05 to get 48 patients. Enrollment criteria and other factors can influence this , of course , so it's not foolproof.