It was the reason why I took a stake in AMBS is 2012, however MANF is an untapped protein.
While it achieved ODD, it was targeted for 1st in-man clinical studies in 2016 under Catalent Pharma who was hired to perform cGMP for clinical-grade production of MANF, but no progress was ever made.
Its been around for decades, but has yet to make it out of preclinicals:
It sits in pre-clinicals 'proof of concept' for RP, RAO, AMD, DB, PK and MYO-CDI.
If it truly holds the possibility of being a genuine game changer, then why hasn't Gerald advanced it forward given unlimited time and opportunities to do so?